Scaling up downstream processing is widely regarded as one of the most complex steps in biomanufacturing. However, many of the challenges associated with scale-up are driven by long-standing assumptions and rules of thumb that do not always hold true in practice.

This workshop will focus on separating fact from fiction in downstream bioprocessing scale-up, with emphasis on four key unit operations: centrifugation, homogenisation, tangential flow filtration and chromatography. Using real-world examples and industrial experience, the session will examine common misconceptions, typical failure points, and the true drivers of performance and risk at scale.

The workshop is led by IBioIC’s FlexBIO Scale-Up Centre, with technical support from our close collaborator GEA. By combining FlexBIO’s applied scale-up capability with GEA’s industrial equipment and process expertise, the session brings together practical development insight and real manufacturing experience. This ensures the discussion is grounded in real-world challenges and solutions across key downstream unit operations.

With dedicated discussion on TFF and chromatography, complemented by insights into centrifugation and homogenisation, the workshop will provide a practical and balanced view of how downstream operations behave when processes move from development to manufacturing.

Why Attend?

• Challenge widely held assumptions about downstream scale-up

• Learn which risks are real and which are often overestimated

• Gain practical insight into scaling with confidence

• Understand how to identify true bottlenecks across downstream unit operations

• Take away lessons that can be directly applied to your own DSP processes